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Alan Eastman Selected Research

Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)

8/2020AT101 [(-)-Gossypol] Selectively Inhibits MCL1 and Sensitizes Carcinoma to BH3 Mimetics by Inducing and Stabilizing NOXA.
1/2019Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477.
1/2016BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics.

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Alan Eastman Research Topics

Disease

36Neoplasms (Cancer)
08/2021 - 07/2002
7Breast Neoplasms (Breast Cancer)
10/2018 - 07/2002
7Leukemia
01/2014 - 05/2002
6B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2016 - 04/2010
2Glioma (Gliomas)
04/2015 - 01/2014
2Hypoxia (Hypoxemia)
01/2014 - 12/2006
2Hypersensitivity (Allergy)
12/2009 - 02/2004
1Carcinoma (Carcinomatosis)
08/2020
1Glioblastoma (Glioblastoma Multiforme)
01/2019
1Urinary Bladder Neoplasms (Bladder Cancer)
09/2017
1Hyperoxia
04/2015
1Weight Loss (Weight Reduction)
02/2013
1Multiple Myeloma
01/2013
1Lymphoma (Lymphomas)
04/2010
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
12/2009
1Liposarcoma
01/2009
1Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
12/2006
1Ischemia
12/2006
1Hyperglycemia
12/2006
1Atrial Fibrillation
12/2006
1Myeloid Leukemia (Leukemia, Myelocytic)
08/2006
1Genomic Instability
02/2004
1Nijmegen Breakage Syndrome
02/2004
1Ataxia Telangiectasia (Louis Bar Syndrome)
02/2004
1Cystic Fibrosis (Mucoviscidosis)
05/2003
1Cadaver (Cadavers)
02/2003

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
08/2021 - 05/2003
77-hydroxystaurosporine (UCN 01)IBA
11/2009 - 07/2002
6DNA (Deoxyribonucleic Acid)IBA
06/2019 - 02/2003
5MK-8776IBA
01/2016 - 01/2012
4GemcitabineFDA Link
09/2017 - 12/2013
3Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA
08/2020 - 01/2016
3Pharmaceutical PreparationsIBA
01/2017 - 12/2006
3Vinblastine (Vinblastine Sulfate)FDA Link
08/2013 - 04/2010
2GossypolIBA
08/2020 - 06/2014
2Messenger RNA (mRNA)IBA
08/2020 - 05/2012
2Paclitaxel (Taxol)FDA LinkGeneric
10/2018 - 08/2011
2Oxygen (Dioxygen)IBA
04/2015 - 01/2014
2carbogenIBA
04/2015 - 01/2014
2ABT-737IBA
01/2014 - 08/2013
2Caspase 3 (Caspase-3)IBA
02/2013 - 05/2002
2Conjugated Linoleic AcidsIBA
02/2013 - 01/2009
2deoxyribonuclease II (DNASE II)IBA
05/2003 - 02/2003
1Cyclin AIBA
01/2021
1gossypol acetic acidIBA
08/2020
1venetoclaxIBA
01/2019
1Checkpoint Kinase 1IBA
01/2019
1Estrogen Receptor betaIBA
01/2019
1Estrogen ReceptorsIBA
10/2018
1Phosphotransferases (Kinase)IBA
10/2018
1SteroidsIBA
01/2018
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
09/2017
1Vinca AlkaloidsIBA
01/2017
1JNK Mitogen-Activated Protein KinasesIBA
01/2016
1ColchicineFDA LinkGeneric
01/2016
1TubulinIBA
01/2016
1BNC 105IBA
01/2016
1pevonedistatIBA
03/2014
1Enzyme Inhibitors (Inhibitors, Enzyme)IBA
03/2014
1lithium phthalocyanineIBA
01/2014
1Thrombospondin 1IBA
01/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2014
1navitoclaxIBA
08/2013
1EnzymesIBA
02/2013
1Lipoprotein Lipase (Diacylglycerol Lipase)IBA
02/2013
1Fatty Acids (Saturated Fatty Acids)IBA
02/2013
1Proteasome InhibitorsIBA
01/2013
1Bortezomib (Velcade)FDA Link
01/2013
1nutlin 3IBA
09/2012
1Hydroxyurea (Hydrea)FDA LinkGeneric
02/2012
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2012
1Cyclin-Dependent Kinases (cdk Proteins)IBA
08/2011
1dinaciclibIBA
08/2011
1alvocidib (flavopiridol)IBA
08/2011
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
04/2010
12- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
04/2010
1DNA Methyltransferase 3BIBA
12/2009
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
01/2009
1Palmitic Acid (Hexadecanoic Acid)IBA
01/2009
1MAP-kinase-activated kinase 2IBA
06/2008
1Cyclin BIBA
02/2008
1Tumor Suppressor Protein p53IBA
01/2007
1PlatinumIBA
12/2006
1Biomarkers (Surrogate Marker)IBA
12/2006
1Glycoproteins (Glycoprotein)IBA
12/2006
1Cisplatin (Platino)FDA LinkGeneric
12/2006
1GemininIBA
12/2006
1phorbolIBA
08/2006
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
09/2005
1MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA
09/2005
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
09/2005
1MitogensIBA
09/2005
1AnisomycinIBA
10/2004
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2004
1Caffeine (No Doz)FDA LinkGeneric
02/2004
1Blood Proteins (Serum Proteins)IBA
10/2002
1Topoisomerase I InhibitorsIBA
07/2002

Therapy/Procedure

12Therapeutics
08/2021 - 10/2002
3Drug Therapy (Chemotherapy)
01/2017 - 01/2014
2Radiotherapy
01/2014 - 11/2009